Possible Side
effects:
- Hematopoetic:
decrease in blood cells, especially white
cells (neutropenia) but also red cells
(anemia) and or platelets
(thrombocytopenia)
- Gastrointestinal:
mild to moderate nausea and vomiting
(which may be decreased or prevented with
medications); diarrhea; mouth sores;
decreased appetite; abnormalities in
liver function tests; inflammation of the
pancreas (pancreatitis); taste changes
- Integmentary:
hair loss (usually complete); changes in
nails
- Fertility:
effect on fertility is unknown; this drug
should not be taken by women who are
pregnant or breast feeding
- Cardiovascular:
chest pain; increase in blood pressure
(hypertension); low blood pressure
(hypotension); slowing of the heart beat
(bradycardia); serious heart problems are
rare (1.5%) in patients who do not have a
history of heart problems; irritation to
the vein where the drug is given
(phlebitis)
- Neurological:
numbness, tingling and/or burning
sensations in hands and/or feet
(peripheral neuropathy); weakness in the
hands and/or feet
- Allergic
(hypersensitivity reactions):
flushing, rash, chest pain or heaviness,
back pain, shortness of breath, wheezing,
fever, shaking, chills, low blood counts.
IT IS
IMPORTANT THAT PATIENTS RECEIVE MEDICINES TO
PREVENT HYPERSENSITIVITY REACTIONS BEFORE EACH
DOSE OF PACLITAXEL
- Other:
fatigue; muscle aches (myalgia) and joint
pain (arthralgia)
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