MALE BREAST CANCER

BREAST CANCER IN MALE PATIENTS (SUMMARY)

EPIDEMIOLOGICAL STATISTICS
	BREAST CANCER MALE PATIENTS FEMALE PATIENTS CASES PER YEAR IN US 1000 182000
CLINICAL PRESENTATION
	-Unilateral, Hard, Breast Mass -Bloody Nipple Discharge -Pain and or Tenderness -Mean age at presentation: 59 Years
SPECIFIC RISK FACTORS FOR MALE PATIENTS
	-Cirrhosis -Liver diseases -Gynecomastia -Klinefelter's Syndrome -Hyper-estrogenism
IMAGING AND DIAGNOSTIC STUDIES
	-Mammography (Essential) - FNA and Core Biopsy
HISTOLOGICAL TYPES
	-Invasive Ductal Carcinoma - Most Frequent -Invasive Lobular Carcinoma - Extremely Rare -All Cell types can be found
STANDARD TREATMENT FOR LOCALLY INVASIVE CARCINOMA
	-Surgical / Local: Same guidelines used for female patients -Systemic: Same guidelines used for female patients -Hormonal: Debatable / Same guidelines used for female patients
STANDARD TREATMENT FOR DISTANT METASTASIS
	-Initial Approach: Orchiectomy versus Tamoxifen -Secondary Approach: Systemic Chemotherapy if no response to hormonal manipulation
PROGNOSIS
	OVERALL SURVIVAL STAGE I 90 % at 10 YEARS Less than 2 cm 53 % at 5 YEARS 2 to 5 cm 44 % at 5 YEARS More 5 cm 25 % at 5 YEARS From Initial Appearance of Distant Metastasis 26.5 months Average Survival

References:

• Patel HZ et al.: Male breast cancer. 1989;64:1583
• Demeter JG et al: Breast cancer in the male patient. Cancer 1990;65:2342